Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

On October 25, 1946, three weeks after the International Military Tribunal at Nuremberg entered its verdicts, the United States established Military Tribunal I for the trial of twenty-three Nazi physicians. The charges, delivered by Brigadier General Telford Taylor on December 9, 1946, form a seminal chapter in the history of medical ethics and, specifically, medical ethics in war. The list of noxious experiments conducted on civilians and prisons of war, and condemned by the Tribunal as war crimes and as crimes (...) against humanity, is by now more or less familiar. That list included: high-altitude experiments; freezing experiments; malaria experiments; sulfanilamide experiments; bone, muscle, and nerve regeneration and bone transplantation experiments; sea water experiments; jaundice and spotted fever experiments; sterilization experiments; experiments with poison and with incendiary bombs. What remains less familiar is the moral mindset of doctors and health care workers who plied their medical skill for morally questionable uses in war. In his 1981 work, The Nazi Doctors, Robert Jay Lifton took up that question, interviewing doctors, many of whom for forty years continued to distance themselves psychologically from their deeds. The questions about moral distancing Lifton raised have immediate urgency for us now. Military medical doctors, psychiatrists and psychologists serve in U.S. military prisons in Guantánamo, Abu Ghraib, Kandahar, and, until very recently, in undisclosed CIA operated facilities around the world where medical ethics are again at issue. Moreover, they serve in top positions in the Pentagon, as civilian and military heads of command, who pass orders and regulations to military doctors in the field, and who are in charge of the health of enemy combatants, as well as U.S. soldiers. Because we recently marked the sixtieth anniversary of the judgment at Nuremberg, I want to awaken our collective memory to the ways in which doctors in war, even in a war very different from the one the Nazis fought, can insulate themselves from their moral and professional consciences. (shrink)

As technology redefines relationships, new assumptions are emerging about the ethics of persuasion. In an increasingly global economy, technology is forcing greater transparency onto businesses and governments as the moral context of their communications is inseparable from the competitive nature of the business world. This article suggests that moral boundaries will be set naturally, that consumers have a moral obligation to excercise "due diligence" in their acceptance of messages, and that no one is in charge of the global economy's conventions (...) and morality. The system ultimately depends on participants to keep their own self-interested boat in the race. (shrink)

The Blackwell Guide to Continental Philosophy is an accessible but sophisticated introduction to the most important figures in Continental philosophy in the last 200 years. Presents a definitive introduction to the core figures and topics of continental philosophy. Contains newly commissioned essays, all of which are written by internationally distinguished scholars. Provides a solid foundation for further study. Subjects include Hegel, Schopenhauer, Kierkegaard, Marx and Marxism, Nietzsche, Husserl and Phenomenology, Heidegger, Sartre, critical theory, Habermas, Gadamer, Foucault, Derrida, postmodernism, and French (...) feminism. (shrink)

This article is an accompaniment to Anthony Freeman’s review of Views into the Chinese Room, reflecting on some pertinent outstanding questions about the Chinese room argument. Although there is general agreement in the artificial intelligence community that the CRA is somehow wrong, debate continues on exactly why and how it is wrong. Is there a killer counter-argument and, if so, what is it? One remarkable fact is that the CRA is prototypically a thought experiment, yet it has been very little (...) discussed from the perspective of thought experiments in general. Here, I argue that the CRA fails as a thought experiment because it commits the fallacy of undersupposing, i.e., it leaves too many details to be filled in by the audience. Since different commentators will often fill in details differently, leading to different opinions of what constitutes a decisive counter, the result is 21-plus years of inconclusive debate. (shrink)

We begin with the history of the discovery of computability in the 1930’s, the roles of Gödel, Church, and Turing, and the formalisms of recursive functions and Turing automatic machines . To whom did Gödel credit the definition of a computable function? We present Turing’s notion [1939, §4] of an oracle machine and Post’s development of it in [1944, §11], [1948], and finally Kleene-Post [1954] into its present form. A number of topics arose from Turing functionals including continuous functionals on (...) Cantor space and online computations. Almost all the results in theoretical computability use relative reducibility and o-machines rather than a-machines and most computing processes in the real world are potentially online or interactive. Therefore, we argue that Turing o-machines, relative computability, and online computing are the most important concepts in the subject, more so than Turing a-machines and standard computable functions since they are special cases of the former and are presented first only for pedagogical clarity to beginning students. At the end in §10–§13 we consider three displacements in computability theory, and the historical reasons they occurred. Several brief conclusions are drawn in §14. (shrink)

This important new text establishes a framework for discussing, understanding, and ultimately making sound decisions on meeting these ethical challenges.

In this essay I will discuss and appraise two conflicting answers to the question of whether there was a crisis in Ptolemaic astronomy prior to the Copernican revolution. I will begin by giving a brief account of why anybody should be interested in this question. I will discuss the two conflicting answers of Kuhn (1962, 1970), who claims to present evidence which shows that Ptolemaic astronomy was anomaly-ridden at the time of Copernicus, and of Gingerich (1975), who claims that the (...) supposed anomalies, which have been passed down in the historical literature due to poor scholarship, are fictitious. Finally I will appraise Gingerich’s criticism of Kuhn, giving my own evaluation of Gingerich’s arguments. I conclude that Gingerich’s arguments against the existence of a technical crisis in Ptolemaic astronomy prior to Copernicus appear to be, either arguments against the efficacy of the Copernican system, or arguments based on definitions of complexity which are not directly attributable to Kuhn. (shrink)

We consider the informal concept of "computability" or "effective calculability" and two of the formalisms commonly used to define it, "(Turing) computability" and "(general) recursiveness". We consider their origin, exact technical definition, concepts, history, general English meanings, how they became fixed in their present roles, how they were first and are now used, their impact on nonspecialists, how their use will affect the future content of the subject of computability theory, and its connection to other related areas. After a careful (...) historical and conceptual analysis of computability and recursion we make several recommendations in section §7 about preserving the intensional differences between the concepts of "computability" and "recursion." Specifically we recommend that: the term "recursive" should no longer carry the additional meaning of "computable" or "decidable;" functions defined using Turing machines, register machines, or their variants should be called "computable" rather than "recursive;" we should distinguish the intensional difference between Church's Thesis and Turing's Thesis, and use the latter particularly in dealing with mechanistic questions; the name of the subject should be "Computability Theory" or simply Computability rather than "Recursive Function Theory.". (shrink)

"This book discusses the vast and complex range of choices in between blanket amnesty and total accountability through criminal justice, and does so with ...

Debates over vaccine mandates raise intense emotions, as reflected in the current controversy over whether to mandate the vaccine against human papilloma virus (HPV), the virus that can cause cervical cancer. Public health ethics so far has failed to facilitate meaningful dialogue between the opposing sides. When stripped of its emotional charge, the debate can be framed as a contest between competing ethical values. This framework can be conceptualized graphically as a conflict between autonomy on the one hand, which militates (...) against government intrusion, and beneficence, utilitarianism, justice, and nonmaleficence on the other, which may lend support to intervention. When applied to the HPV vaccine, this framework would support a mandate based on utilitarianism, if certain conditions are met and if herd immunity is a realistic objective. (shrink)

The psychological concept of illusion is defined as a process involving an interaction of logical and empirical considerations. Common usage suggests that an illusion is a discrepancy between one's awareness and some stimulus. Following preliminary definitions of classes of stimuli, five definitions of illusion are considered, based upon the possible discrepancies between awareness and a stimulus. It is found that each of these definitions fails to make important distinctions, even to the point of equating all illusory and perceptual phenomena. This (...) dilemma is resolved by redefining illusion without reference to truth or falsity, but relative to the functioning of a given perceptual system under different conditions. The definition accepted as best is 'a discrepancy between one's perceptions of an object or event observed under different conditions'. Conditions may differ in terms of stimulus exposure, stimulus context, or experiental context. The philosophical and psychological implications are discussed of accepting a definition of illusion not based on a discrepancy between awareness and a stimulus. (shrink)

In developing a framework for assessing privacy risks, Dupras and Bunnik’s “Toward a framework for assessing privacy risks in multi-omic research and databases” considers the question of whe...

A human document of historic interest concerning a good-will mission to wartime England filled with trenchant and witty observation of its brave and stoical people.

John Searle’s Chinese room argument is a celebrated thought experiment designed to refute the hypothesis, popular among artificial intelligence scientists and philosophers of mind, that “the appropriately programmed computer really is a mind”. Since its publication in 1980, the CRA has evoked an enormous amount of debate about its implications for machine intelligence, the functionalist philosophy of mind, theories of consciousness, etc. Although the general consensus among commentators is that the CRA is flawed, and not withstanding the popularity of the (...) systems reply in some quarters, there is remarkably little agreement on exactly how and why it is flawed. A newcomer to the controversy could be forgiven for thinking that the bewildering collection of diverse replies to Searle betrays a tendency to unprincipled, ad hoc argumentation and, thereby, a weakness in the opposition’s case. In this paper, treating the CRA as a prototypical example of a ‘destructive’ thought experiment, I attempt to set it in a logical framework, which allows us to systematise and classify the various objections. Since thought experiments are always posed in narrative form, formal logic by itself cannot fully capture the controversy. On the contrary, much also hinges on how one translates between the informal everyday language in which the CRA was initially framed and formal logic and, in particular, on the specific conception of possibility that one reads into the logical formalism. (shrink)

Let M be a smooth, compact manifold of dimension n ≥ 5 and sectional curvature | K | ≤ 1. Let Met (M) = Riem(M)/Diff(M) be the space of Riemannian metrics on M modulo isometries. Nabutovsky and Weinberger studied the connected components of sublevel sets (and local minima) for certain functions on Met (M) such as the diameter. They showed that for every Turing machine T e , e ∈ ω, there is a sequence (uniformly effective in e) of homology (...) n-spheres {P k e } k ∈ ω which are also hypersurfaces, such that P k e is diffeomorphic to the standard n-sphere S n (denoted P k e ≈ diff S n ) iff T e halts on input k, and in this case the connected sum N k e =M ♯ P k e ≈ diff M , so N k e ∈ Met(M), and N k e is associated with a local minimum of the diameter function on Met(M) whose depth is roughly equal to the settling time σ e (k) of T e on inputs y i } ∈ ω of c.e. sets so that for all i the settling time of the associated Turing machine for A i dominates that for A i + 1 , even when the latter is composed with an arbitrary computable function. From this, Nabutovsky and Weinberger showed that the basins exhibit a "fractal" like behavior with extremely big basins, and very much smaller basins coming off them, and so on. This reveals what Nabutovsky and Weinberger describe in their paper on fractals as "the astonishing richness of the space of Riemannian metrics on a smooth manifold, up to reparametrization." From the point of view of logic and computability, the Nabutovsky-Weinberger results are especially interesting because: (1) they use c.e. sets to prove structural complexity of the geometry and topology, not merely undecidability results as in the word problem for groups, Hilbert's Tenth Problem, or most other applications; (2) they use nontrivial information about c.e. sets, the Soare sequence {A i } i ∈ ω above, not merely G öodel's c.e. noncomputable set K of the 1930's; and (3) without using computability theory there is no known proof that local minima exist even for simple manifolds like the torus T 5 (see §). (shrink)